The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.
Identifieur interne : 001649 ( Main/Exploration ); précédent : 001648; suivant : 001650The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.
Auteurs : Phillip J. Tully [France] ; Karine Péres [France] ; Claudine Berr [France] ; Christophe Tzourio [France]Source :
- Neurobiology of aging [ 1558-1497 ] ; 2016.
Descripteurs français
- KwdFr :
- Apolipoprotéine E4 (génétique), Caractères sexuels, Démence (génétique), Dépression (génétique), Facteurs de risque, Femelle, Humains, Mâle, Phénotype, Polymorphisme génétique (génétique), Sujet âgé, Sujet âgé de 80 ans ou plus, Valeur prédictive des tests, Vieillissement (génétique), Études d'associations génétiques.
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Apolipoprotein E4.
- genetics : Aging, Dementia, Depression, Polymorphism, Genetic.
- Aged, Aged, 80 and over, Female, Genetic Association Studies, Humans, Male, Phenotype, Predictive Value of Tests, Risk Factors, Sex Characteristics.
Abstract
The apolipoprotein E ε4 allele (APOE4) is an established risk factor for dementia; however, conflicting findings have been reported as to whether this phenotype confers a heightened risk for late onset depression (LOD) independent of dementia. We examined 2242 persons for incident LOD who also underwent genotyping for APOE4. Major LOD was associated with female sex (odds ratio, 3.61; 95% confidence interval, 1.89-6.90). APOE4 was not associated with major LOD regardless of whether dementia was excluded. In conclusion, we showed that the APOE4 phenotype holds no predictive value for major LOD.
DOI: 10.1016/j.neurobiolaging.2015.12.018
PubMed: 26785975
Affiliations:
- France
- Aquitaine, Languedoc-Roussillon, Nouvelle-Aquitaine, Occitanie (région administrative)
- Bordeaux, Montpellier
- Université Montpellier 1
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002072
- to stream PubMed, to step Curation: 002047
- to stream PubMed, to step Checkpoint: 002047
- to stream Ncbi, to step Merge: 003017
- to stream Ncbi, to step Curation: 003017
- to stream Ncbi, to step Checkpoint: 003017
- to stream Main, to step Merge: 001644
- to stream Main, to step Curation: 001649
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.</title><author><name sortKey="Tully, Phillip J" sort="Tully, Phillip J" uniqKey="Tully P" first="Phillip J" last="Tully">Phillip J. Tully</name><affiliation wicri:level="3"><nlm:affiliation>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; INSERM, Neuroepidemiology, UMR897, Bordeaux, France. Electronic address: phillip.tully@adelaide.edu.au.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; INSERM, Neuroepidemiology, UMR897, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Peres, Karine" sort="Peres, Karine" uniqKey="Peres K" first="Karine" last="Péres">Karine Péres</name><affiliation wicri:level="3"><nlm:affiliation>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Université Montpellier 1, Hôpital La Colombière, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Université Montpellier 1, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement><settlement type="city">Montpellier</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="3"><nlm:affiliation>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26785975</idno><idno type="pmid">26785975</idno><idno type="doi">10.1016/j.neurobiolaging.2015.12.018</idno><idno type="wicri:Area/PubMed/Corpus">002072</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002072</idno><idno type="wicri:Area/PubMed/Curation">002047</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002047</idno><idno type="wicri:Area/PubMed/Checkpoint">002047</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002047</idno><idno type="wicri:Area/Ncbi/Merge">003017</idno><idno type="wicri:Area/Ncbi/Curation">003017</idno><idno type="wicri:Area/Ncbi/Checkpoint">003017</idno><idno type="wicri:Area/Main/Merge">001644</idno><idno type="wicri:Area/Main/Curation">001649</idno><idno type="wicri:Area/Main/Exploration">001649</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.</title><author><name sortKey="Tully, Phillip J" sort="Tully, Phillip J" uniqKey="Tully P" first="Phillip J" last="Tully">Phillip J. Tully</name><affiliation wicri:level="3"><nlm:affiliation>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; INSERM, Neuroepidemiology, UMR897, Bordeaux, France. Electronic address: phillip.tully@adelaide.edu.au.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; Freemasons Foundation Centre for Men's Health, Discipline of Medicine, School of Medicine, The University of Adelaide, Australia; INSERM, Neuroepidemiology, UMR897, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Peres, Karine" sort="Peres, Karine" uniqKey="Peres K" first="Karine" last="Péres">Karine Péres</name><affiliation wicri:level="3"><nlm:affiliation>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Université Montpellier 1, Hôpital La Colombière, Montpellier, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1061, Faculty of Medicine, Hôpital La Colombière, Montpellier, France; Université Montpellier 1, Hôpital La Colombière, Montpellier</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement><settlement type="city">Montpellier</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="3"><nlm:affiliation>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>University of Bordeaux, Neuroepidemiology, UMR897, Bordeaux, France; INSERM, Neuroepidemiology, UMR897, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author></analytic><series><title level="j">Neurobiology of aging</title><idno type="eISSN">1558-1497</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Aging (genetics)</term><term>Apolipoprotein E4 (genetics)</term><term>Dementia (genetics)</term><term>Depression (genetics)</term><term>Female</term><term>Genetic Association Studies</term><term>Humans</term><term>Male</term><term>Phenotype</term><term>Polymorphism, Genetic (genetics)</term><term>Predictive Value of Tests</term><term>Risk Factors</term><term>Sex Characteristics</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Apolipoprotéine E4 (génétique)</term><term>Caractères sexuels</term><term>Démence (génétique)</term><term>Dépression (génétique)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Phénotype</term><term>Polymorphisme génétique (génétique)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Valeur prédictive des tests</term><term>Vieillissement (génétique)</term><term>Études d'associations génétiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoprotein E4</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aging</term><term>Dementia</term><term>Depression</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéine E4</term><term>Démence</term><term>Dépression</term><term>Polymorphisme génétique</term><term>Vieillissement</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Genetic Association Studies</term><term>Humans</term><term>Male</term><term>Phenotype</term><term>Predictive Value of Tests</term><term>Risk Factors</term><term>Sex Characteristics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Caractères sexuels</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Phénotype</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Valeur prédictive des tests</term><term>Études d'associations génétiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The apolipoprotein E ε4 allele (APOE4) is an established risk factor for dementia; however, conflicting findings have been reported as to whether this phenotype confers a heightened risk for late onset depression (LOD) independent of dementia. We examined 2242 persons for incident LOD who also underwent genotyping for APOE4. Major LOD was associated with female sex (odds ratio, 3.61; 95% confidence interval, 1.89-6.90). APOE4 was not associated with major LOD regardless of whether dementia was excluded. In conclusion, we showed that the APOE4 phenotype holds no predictive value for major LOD.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Languedoc-Roussillon</li><li>Nouvelle-Aquitaine</li><li>Occitanie (région administrative)</li></region><settlement><li>Bordeaux</li><li>Montpellier</li></settlement><orgName><li>Université Montpellier 1</li></orgName></list><tree><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Tully, Phillip J" sort="Tully, Phillip J" uniqKey="Tully P" first="Phillip J" last="Tully">Phillip J. Tully</name></region><name sortKey="Berr, Claudine" sort="Berr, Claudine" uniqKey="Berr C" first="Claudine" last="Berr">Claudine Berr</name><name sortKey="Peres, Karine" sort="Peres, Karine" uniqKey="Peres K" first="Karine" last="Péres">Karine Péres</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001649 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001649 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:26785975
|texte= The APOE epsilon 4 polymorphism does not predict late onset depression: the Three-City Study.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26785975" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |